Nanozymes-Enhanced Cell Therapy
- Tianxiao MeiTianxiao MeiInstitute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology & School of Medicine, Tongji University, Shanghai 200092, ChinaMore by Tianxiao Mei
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- Yifan Zhang Yifan ZhangInstitute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology & School of Medicine, Tongji University, Shanghai 200092, ChinaMore by Yifan Zhang
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- Wenjun LeWenjun LeTranslational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital Ji’an Hospital, Jian 343000, ChinaMore by Wenjun Le
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- Yihui Hu*Yihui Hu*Email: [email protected]Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology & School of Medicine, Tongji University, Shanghai 200092, ChinaMore by Yihui Hu
Abstract
Cell therapy, including stem cell therapy and cancer immunotherapy, as a third generation of emerging therapeutic strategy after drug and surgical treatment, has opened up a new horizon for intractable diseases. However, the adverse microenvironment of the lesion sites reduced the efficacy of cell therapy in vivo. Reportedly, nanozymes play prominent roles in modulating microenvironment to improve cell-based therapy. Therefore, in this chapter, we introduce and exemplify the development of nanozymes-based modulation-enhanced strategies for cell therapy, ranging from antioxidant nanozymes improving stem cell therapy to pro- and anti-oxidant nanozymes that activate immune responses. It will provide valuable guidance for the synergism of cell therapy and nanocatalytic therapy.